Research Articles
Multi-Omics Data Integration Frameworks: A Comprehensive Guide for Complex Disease Research and Drug Development
This article provides a comprehensive overview of multi-omics data integration frameworks and their pivotal role in deciphering complex diseases.
Multi-Scale Biological Networks: Bridging Molecular to Organ-Level Physiology for Drug Discovery
This article explores the transformative role of multi-scale biological network models in understanding human physiology and advancing therapeutic development.
Decoding Disease Endotypes: A Systems Biology Approach to Precision Medicine
The paradigm of 'one-size-fits-all' medicine is rapidly giving way to precision medicine, necessitating a deeper understanding of disease heterogeneity.
Diseasome and Disease Networks: A Comprehensive Guide for Biomedical Research and Therapeutic Development
This article provides a comprehensive exploration of diseasome and disease network concepts, bridging foundational theory with cutting-edge applications in biomedical research and drug development.
Network Medicine: Harnessing Interactome Analysis for Disease Gene Discovery and Therapeutic Development
Interactome analysis represents a paradigm shift in biomedical research, moving beyond static gene lists to dynamic network models of disease.
Emergent Properties in Complex Disease Systems: A New Paradigm for Research and Therapeutics
This article explores the paradigm of emergent properties in complex disease systems, a framework that moves beyond traditional reductionist approaches.
Network Medicine: Understanding Disease as a Systemic Defect in Biological Networks
This article explores the paradigm shift in biomedical research from a reductionist view of disease to a network-based understanding of disease as a systemic perturbation of biological interactomes.
Bridging the Genotype-Phenotype Gap in Complex Diseases: From Genomic Architecture to AI-Driven Discovery
This article provides a comprehensive exploration of the strategies and technologies revolutionizing our ability to link complex genotypes to phenotypes, a central challenge in modern biomedical research.
Network Analysis in Disease Pathophysiology: From Systems Biology to Precision Drug Discovery
This article provides a comprehensive overview of network-based approaches for elucidating disease pathophysiology and accelerating drug discovery.
Integrating Multi-Omics Data: Systems Biology Approaches for Unlocking Disease Mechanisms and Advancing Precision Medicine
The integration of multi-omics data—encompassing genomics, transcriptomics, proteomics, and metabolomics—is revolutionizing biomedical research by providing a holistic view of biological systems.