Research Articles
Machine Learning Decodes Autism Heterogeneity: A New Framework for Biologically Distinct ASD Subtypes and Precision Medicine
This article synthesizes the latest breakthroughs in machine learning (ML) for autism spectrum disorder (ASD) subtyping, a pivotal shift from behavior-based to biology-driven classification.
Integrating Multi-Omics in Autism Research: From Molecular Networks to Precision Therapeutics
This article provides a comprehensive overview of the transformative role of multi-omics integration in advancing autism spectrum disorder (ASD) research.
Decoding Autism Heterogeneity: A Tensor Decomposition Framework for fMRI-Based Subtype Discovery
Autism Spectrum Disorder (ASD) is characterized by significant clinical and biological heterogeneity, posing challenges for diagnosis and therapeutic development.
Advanced Strategies for Prioritizing ASD Genes in Large and Noisy Genomic Datasets
The identification of Autism Spectrum Disorder (ASD) risk genes is complicated by the condition's complex genetic architecture and the challenge of discerning true signals within large, noisy genomic datasets.
Network Biology of Autism: Decoding the Protein Interactome for Therapeutic Insights
This article provides a comprehensive overview for researchers and drug development professionals on how topological analysis of Protein-Protein Interaction (PPI) networks is revolutionizing our understanding of Autism Spectrum Disorder (ASD).
Integrating Systems Biology and Copy Number Variant Analysis: From Gene Networks to Clinical Diagnostics
This article explores the powerful integration of copy number variant (CNV) analysis with systems biology approaches to unravel complex genetic architectures in human disease.
Pathway Enrichment Analysis in Autism Research: A Comprehensive Guide to Methods, Applications, and Biomarker Discovery
This article provides a comprehensive guide to Over-Representation Analysis (ORA) and Pathway Enrichment Analysis (PEA) for researchers and drug development professionals working on Autism Spectrum Disorder (ASD).
Building the Blueprint: How Protein-Protein Interaction Networks Are Revealing Autism's Molecular Mechanisms
This article provides a comprehensive overview of the construction and application of Protein-Protein Interaction (PPI) networks in Autism Spectrum Disorder (ASD) research.
Betweenness Centrality for Autism Gene Prioritization: A Systems Biology Framework for Complex Disorder Research
Autism Spectrum Disorder (ASD) presents a complex genetic architecture that traditional genome-wide studies often struggle to decode.
Mapping the Disconnected Mind: Systems Biology Approaches to Brain Connectivity in Autism Spectrum Disorder
This article synthesizes the latest research on brain connectivity patterns in autism spectrum disorder (ASD) through the lens of systems biology.