Research Articles
Contrast Tests for Genetic Interactions: A Comprehensive Guide to Methods, Applications, and Best Practices
Understanding genetic interactions is crucial for unraveling the complex architecture of diseases and traits, yet their detection poses significant statistical and computational challenges.
Regression Models for Epistasis Analysis: A Comprehensive Guide for Biomedical Research
This article provides a comprehensive guide to regression-based models for epistasis analysis, tailored for researchers and drug development professionals.
Computational Frameworks for Complex Disease Stratification: From Multi-Omics Integration to Clinical Translation
Complex diseases like cancer, Alzheimer's, and cardiovascular disorders demand precision medicine approaches that move beyond broad classifications.
Dynamic Modeling of Drug Responses: From Systems Biology to Clinical Translation
This article provides a comprehensive overview of dynamic modeling approaches for predicting and understanding drug responses within the framework of systems biology.
Static Network Modeling of Disease Mechanisms: From Foundational Concepts to Clinical Applications in Drug Discovery
This article provides a comprehensive overview of static network modeling for elucidating disease mechanisms, tailored for researchers, scientists, and drug development professionals.
Network-Guided Biomarker Discovery: Integrating AI, Graphs, and Multi-Omics for Precision Oncology
The complexity of cancer and other complex diseases demands a paradigm shift beyond single-molecule biomarkers.
Module Identification in Biological Networks: Unraveling Disease Mechanisms for Drug Discovery
This article provides a comprehensive overview of module identification in biological networks and its pivotal role in understanding complex diseases.
Pathway Enrichment Analysis for Complex Diseases: A Comprehensive Guide from Foundations to Clinical Translation
Pathway enrichment analysis has become an indispensable knowledge-based approach for interpreting high-throughput omics data in complex disease research.
Protein-Protein Interaction Networks: Decoding Disease Mechanisms and Accelerating Drug Discovery
This article provides a comprehensive overview of the pivotal role Protein-Protein Interaction (PPI) networks play in understanding complex diseases and advancing therapeutic development.
From Data to Discovery: A Modern Guide to Gene Regulatory Network Inference
This article provides a comprehensive overview of the rapidly evolving field of Gene Regulatory Network (GRN) inference, a critical computational challenge in systems biology and drug discovery.